4 years ago, the Great Pacific Rotation shook the world; the quakes that hit Japan and New Zealand were soon followed by the Nazca Tsunami, the great Atitlán Eruption, the Superquake in California, and the more minor Seattle Quake.
The Atitlán Eruption was the most destructive, and literally changed the world. The plume from the eruption pierced the stratosphere, rising 43 km. More importantly it carried with it some form of spores or seeds that spread world-wide. These spores produced a highly toxic reaction in people that were exposed; about 1 in every 5,000 people were hospitalized. Of those, only 1 in 10 lived.